Description

tert-Butyl 4-Iodo-5-Methoxypyridin-3-Ylcarbamate is a high-purity, advanced pharmaceutical intermediate characterized by its pyridine core with iodine and carbamate functional groups. This compound is of significant value for its role as a versatile building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization stages for introducing the iodopyridine moiety via cross-coupling reactions like Suzuki or Sonogashira.
• Agrochemical Synthesis: Serves as a building block for developing novel crop protection agents and pesticides.
• Chemical Biology Probes: Utilized in the creation of molecular probes and labeled compounds for biochemical and pharmacological studies.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale production of APIs.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and CDMO (Contract Development and Manufacturing Organization) services.

Basic Information

Product Name	tert-Butyl 4-Iodo-5-Methoxypyridin-3-Ylcarbamate
CAS No.	1045858-08-9
Molecular Formula	C11H15IN2O3
Molecular Weight	350.15 g/mol
Synonyms	tert-Butyl (4-iodo-5-methoxypyridin-3-yl)carbamate; 3-((tert-Butoxycarbonyl)amino)-4-iodo-5-methoxypyridine; 4-Iodo-5-methoxy-3-pyridinylcarbamic Acid 1,1-Dimethylethyl Ester; tert-Butyl N-(4-iodo-5-methoxypyridin-3-yl)carbamate; BOC-4-Iodo-5-Methoxypyridin-3-Amine; 1045858-08-9; tert-Butyl 4-iodo-5-methoxy-3-pyridinylcarbamate
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Iodo-5-Methoxypyridin-3-Ylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee batch-to-batch consistency and support your regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.