Description

5-Bromo-2-Iodopyridin-3-Yl Acetate is a high-value halogenated pyridine derivative, a crucial building block in modern synthetic organic chemistry. Its strategic molecular structure, featuring both bromine and iodine substituents, makes it an exceptionally versatile intermediate for constructing complex molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in cross-coupling reactions, medicinal chemistry, and material science.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drug candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the halogenated pyridine core is a common pharmacophore.
• Cross-Coupling Reactions: Serves as an excellent substrate for Suzuki-Miyaura, Stille, and Negishi couplings due to the differential reactivity of the bromine and iodine atoms, enabling sequential functionalization.
• Material Science Research: Employed in the creation of organic electronic materials, ligands for catalysts, and advanced polymers.
• Medicinal Chemistry & SAR Studies: Utilized to explore structure-activity relationships by introducing the halogenated acetate moiety into lead compounds.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and reference standards.

Basic Information

Product Name	5-Bromo-2-Iodopyridin-3-Yl Acetate
CAS No.	1045858-04-5
Molecular Formula	C7H5BrINO2
Molecular Weight	341.93 g/mol
Synonyms	3-Acetoxy-5-bromo-2-iodopyridine; (5-Bromo-2-iodopyridin-3-yl) acetate; 5-Bromo-2-iodopyridin-3-ol acetate; Acetic acid 5-bromo-2-iodopyridin-3-yl ester; 2-Iodo-5-bromopyridin-3-yl acetate; 3-Pyridinol, 5-bromo-2-iodo-, acetate (ester); 1045858-04-5 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Iodopyridin-3-Yl Acetate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, essential for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of research and development, as well as pre-clinical scale-up phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in its original packaging to minimize exposure to moisture and air. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.