Description

4-Chloro-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine-5-Boronic Acid Pinacol Ester is a high-value, advanced pharmaceutical intermediate and building block for organic synthesis. This compound is specifically engineered for use in cross-coupling reactions, most notably the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecular architectures. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those containing the pyrrolopyridine scaffold for kinase inhibitors and other targeted therapies.
• Suzuki-Miyaura Cross-Coupling: The boronic ester functional group makes this compound a critical reagent for forming carbon-carbon bonds, enabling the construction of biaryl and heterobiaryl structures central to modern medicinal chemistry.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the chloropyrrolopyridine moiety can impart specific biological activity.
• Material Science & OLED Development: Serves as a precursor for creating organic electronic materials, including charge-transport layers and emissive materials in organic light-emitting diodes (OLEDs).
• Chemical Biology & Probe Development: Utilized in creating molecular probes and labeled compounds for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	4-Chloro-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine-5-Boronic Acid Pinacol Ester
CAS No.	1045857-94-0
Molecular Formula	C22H36BCIN2O2Si
Molecular Weight	434.89 g/mol
Synonyms	4-Chloro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine-5-boronic acid pinacol ester; 1H-Pyrrolo[2,3-b]pyridine-5-boronic acid, 4-chloro-1-(triisopropylsilyl)-, 1,1-dimethylethyl ester; 4-Chloro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ylboronic acid pinacol ester; 4-Chloro-1-TIPS-1H-pyrrolo[2,3-b]pyridine-5-boronic acid pinacol ester; 4-Chloro-1-TIPS-7-azaindole-5-boronic acid pinacol ester; TIPS-4-Chloro-7-azaindole-5-boronate pinacol ester; CAS 1045857-94-0
EINECS	Contact for details

Quality Control

Our production of 4-Chloro-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine-5-Boronic Acid Pinacol Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials are characterized by advanced analytical techniques including NMR, HPLC, and LC-MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.