Description

3-((tert-Butyldimethylsilyloxy)Methyl)-5-Methoxypyridine is a high-value, protected pyridine derivative used as a critical synthetic intermediate in advanced organic chemistry. This compound is essential for constructing complex molecular architectures where selective protection and functionalization of hydroxyl groups are required. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in drug discovery and fine chemical synthesis. The CAS number for this material is 1045855-62-6.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting neurological and oncological pathways.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, leveraging its pyridine core for biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for sophisticated ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic electronic materials and advanced polymers due to its functionalized aromatic system.
• Academic & Contract Research: A valuable reagent for methodological development in organic synthesis within academic laboratories and CROs (Contract Research Organizations).
• Peptide Mimetics & Prodrug Design: The silyl-protected alcohol moiety is useful for creating prodrug linkages and modifying peptide-like structures to enhance stability and bioavailability.

Basic Information

Product Name	3-((tert-Butyldimethylsilyloxy)Methyl)-5-Methoxypyridine
CAS No.	1045855-62-6
Molecular Formula	C13H23NO2Si
Molecular Weight	253.41 g/mol
Synonyms	5-Methoxy-3-(((tert-butyldimethylsilyl)oxy)methyl)pyridine; 3-(((tert-Butyldimethylsilyl)oxy)methyl)-5-methoxypyridine; 5-Methoxy-3-pyridinemethanol, 1,1-dimethylethyl[dimethylsilyl] ether; TBDMS-Protected 5-Methoxy-3-pyridinemethanol; (5-Methoxypyridin-3-yl)methyl tert-butyldimethylsilyl ether
EINECS	Contact for details

Quality Control

Every batch of 3-((tert-Butyldimethylsilyloxy)Methyl)-5-Methoxypyridine is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency. Our standard quality commitment includes comprehensive analysis via HPLC, GC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles. We support development and commercial projects with specifications tailored to meet cGMP and ICH guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.