Description

Etrolizumab is a humanized monoclonal antibody designed for targeted therapeutic intervention. This compound is of significant interest in the development of advanced biologic treatments for immune-mediated inflammatory conditions. It is primarily utilized by pharmaceutical research and development teams, biotechnology companies, and clinical manufacturing organizations focused on next-generation immunology therapies.

Application

• Pharmaceutical Active Ingredient (API): Serves as the core active component in biologic drug formulations.
• Immunology Research: Used as a critical tool in preclinical and clinical studies investigating inflammatory bowel disease (IBD) pathways.
• Biologic Drug Development: Integral to the R&D pipeline for novel monoclonal antibody-based therapies targeting specific integrins.
• Clinical Trial Material (CTM): Supplied as a high-purity reference standard or bulk material for clinical-stage manufacturing.
• Mechanism of Action Studies: Employed in biochemical and cellular assays to study α4β7 integrin inhibition.
• Biosimilar Development: Acts as a reference molecule for analytical characterization and comparability studies.

Basic Information

Item	Detail
Product Name	Etrolizumab
CAS No.	1044758-60-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	rhuMAb β7; Anti-Integrin α4β7 Monoclonal Antibody; Etrolizumab (USAN/INN); PRO145223; RG7413; α4β7 Integrin Inhibitor; Anti-α4β7 Antibody; hMAb β7
EINECS	Contact for details

Quality Control

Our Etrolizumab is manufactured under stringent quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and potency, SDS-PAGE and CE-SDS for identity and aggregation, and endotoxin and bioburden testing. A detailed Certificate of Analysis (COA) documenting compliance with relevant specifications is provided with every shipment to ensure traceability and regulatory support for your projects.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C to -80°C. Avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive) and should be handled under controlled, dry conditions to maintain integrity.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear to slightly opalescent solution
Identification (Mass Spec)	Conforms
Purity (SEC-HPLC)	≥ 98.0% (Monomer)
Potency (Cell-based Assay)	Contact for details
Protein Content (A280)	As per COA
Endotoxin	< 1.0 EU/mg
pH	6.0 - 7.5 (for solution)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.