Description

(2E)-1-(2-Hydroxy-4,6-Dimethoxy-3-Methylphenyl)-3-(4-Hydroxyphenyl)-2-Propen-1-One is a specialized chalcone derivative, a class of compounds known for their significant biological and chemical activity. This high-purity intermediate is valued for its role as a key building block in advanced organic synthesis and pharmaceutical research. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, particularly those targeting inflammation, cancer, and metabolic disorders.
• Agrochemical Research: Used in developing new generation pesticides and herbicides, leveraging its chalcone backbone for bioactive molecule design.
• Fine Chemical Synthesis: Acts as a versatile building block for creating complex organic molecules, dyes, and functional polymers.
• Biochemical Probe Development: Utilized in research to study enzyme inhibition and cellular signaling pathways due to its specific structural motifs.
• Cosmetic Ingredient Research: Investigated for potential use in skincare formulations for its antioxidant and UV-absorbing properties derived from the phenolic structure.
• Material Science: Explored as a monomer or additive for creating advanced polymeric materials with specific optical or electronic characteristics.

Basic Information

Product Name	(2E)-1-(2-Hydroxy-4,6-Dimethoxy-3-Methylphenyl)-3-(4-Hydroxyphenyl)-2-Propen-1-One
CAS No.	1044743-35-2
Molecular Formula	C18H18O5
Molecular Weight	314.33 g/mol
Synonyms	2'-Hydroxy-4,6-dimethoxy-3'-methylchalcone; 3-(4-Hydroxyphenyl)-1-(2-hydroxy-4,6-dimethoxy-3-methylphenyl)prop-2-en-1-one; (E)-1-(2-Hydroxy-4,6-dimethoxy-3-methylphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one; 4,6-Dimethoxy-3-methyl-2'-hydroxy-4'-hydroxychalcone; Dimethylxanthohumol analog; NSC 760463; Chalcone derivative CAS 1044743-35-2
EINECS	Contact for details

Quality Control

Our (2E)-1-(2-Hydroxy-4,6-Dimethoxy-3-Methylphenyl)-3-(4-Hydroxyphenyl)-2-Propen-1-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformance to specification.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.