Description

tert-Butyl 4-(tert-Butoxycarbonylamino)-2,6-dichloronicotinate is a high-purity, protected nicotinic acid derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role as a key synthetic intermediate in the development of complex pharmaceutical molecules, particularly in medicinal chemistry research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing novel heterocyclic scaffolds. The product is supplied with a focus on batch-to-batch consistency and reliable purity to support sensitive multi-step syntheses.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting kinase inhibition or other heterocycle-dependent biological pathways.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Agrochemical Synthesis: Serves as a building block for developing new active ingredients with complex pyridine-based structures.
• Fine Chemical Production: Employed in custom synthesis and contract manufacturing of specialty chemicals requiring protected amino-nicotinate motifs.
• Academic Research: Utilized in university and institutional labs for methodological development in organic synthesis and heterocyclic chemistry.
• Peptidomimetic Development: The tert-butyloxycarbonyl (Boc) and tert-butyl ester protecting groups make it suitable for constructing peptide-like molecules and prodrugs.

Basic Information

Item	Detail
Product Name	tert-Butyl 4-(tert-Butoxycarbonylamino)-2,6-Dichloronicotinate
CAS No.	1044148-92-6
Molecular Formula	C15H20Cl2N2O4
Molecular Weight	363.24 g/mol
Synonyms	2,6-Dichloro-4-[(tert-butoxycarbonyl)amino]nicotinic acid tert-butyl ester; 4-[(tert-Butoxycarbonyl)amino]-2,6-dichloropyridine-3-carboxylic acid tert-butyl ester; tert-Butyl 4-(Boc-amino)-2,6-dichloronicotinate; 2,6-Dichloro-4-((tert-butoxycarbonyl)amino)nicotinic acid tert-butyl ester; Boc-4-Amino-2,6-dichloronicotinic acid tert-butyl ester; 1044148-92-6; tert-Butyl 4-((tert-butoxycarbonyl)amino)-2,6-dichloropyridine-3-carboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(tert-Butoxycarbonylamino)-2,6-dichloronicotinate is manufactured under controlled conditions to ensure high chemical purity and structural integrity, suitable for demanding synthetic applications. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) documenting all test results are provided with every shipment. Our quality management system supports compliance with cGMP and ISO standards for research-grade chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.