Description

Aminooxy-PEG2-Azide is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring an aminooxy group and an azide terminus. This compound is specifically engineered for bioorthogonal conjugation strategies, enabling the efficient and selective labeling of biomolecules under mild, aqueous conditions. It is an essential reagent for researchers and manufacturers in bioconjugation, pharmaceutical development, and advanced material science, facilitating the creation of antibody-drug conjugates (ADCs), PEGylated therapeutics, and functionalized surfaces.

Application

• Bioconjugation and ADC Development: Site-specific conjugation of drugs, toxins, or fluorophores to antibodies or proteins via oxime ligation (aminooxy) and copper-free click chemistry (azide).
• PEGylation Linker: Used as a hydrophilic spacer to improve the solubility, stability, and pharmacokinetic profiles of therapeutic peptides and proteins.
• Surface Functionalization: Modification of nanoparticles, microarrays, and biosensor surfaces for immobilizing biomolecules or creating bioactive coatings.
• Polymer Chemistry: Building block for synthesizing functionalized polymers and hydrogels with tailored biological activity.
• Chemical Biology Probes: Synthesis of activity-based probes for studying enzyme function or metabolic pathways in live cells.
• Diagnostic Reagent Synthesis: Creation of labeled antigens or antibodies for immunoassays and diagnostic kits.

Basic Information

Product Name	Aminooxy-PEG2-Azide
CAS No.	1043426-13-6
Molecular Formula	C11H22N4O5
Molecular Weight	290.32 g/mol
Synonyms	Azido-PEG2-Aminooxy; 2-[2-(2-Azidoethoxy)ethoxy]ethylaminooxy; Aminooxy-PEG2-N3; 11-Azido-3,6,9-trioxa-11-azaundecan-1-amine oxide; O-(2-Aminooxyethyl)-O'-(2-azidoethyl)diethylene glycol; Aminooxy-PEG2-Azide crosslinker; Heterobifunctional PEG linker, Aminooxy/Azide
EINECS	Contact for details

Quality Control

Our Aminooxy-PEG2-Azide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent performance for sensitive bioconjugation applications. A comprehensive Certificate of Analysis (COA) is provided, detailing purity, identity, and functional group integrity as verified by HPLC, NMR, and MS. We support compliance with cGMP and ISO 9001 standards for research and pre-clinical manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term stability, store under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Assay (Aminooxy)	≥ 90%
Functional Group Assay (Azide)	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.