Description

3-Chloro-n-Ethyl-5-(Trifluoromethyl)-2-Pyridinamine is a high-purity, advanced pharmaceutical intermediate characterized by its pyridine core substituted with chloro, ethylamino, and trifluoromethyl groups. This compound is valued for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and metabolic disorders. It is essential for research and development chemists and process scale-up teams in the pharmaceutical and agrochemical industries seeking to introduce specific halogenated and fluorinated motifs into their molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, especially in neuropharmacology and oncology.
• Agrochemical Research: Used in the synthesis of advanced herbicides and pesticides, leveraging the biological activity of the pyridine and trifluoromethyl groups.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organometallic chemistry.
• Material Science: Investigated as a monomer or additive for the development of specialty polymers with unique electronic or surface properties.
• Chemical Biology Probes: Utilized in the design of molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	3-Chloro-n-Ethyl-5-(Trifluoromethyl)-2-Pyridinamine
CAS No.	1042499-48-8
Molecular Formula	C8H8ClF3N2
Molecular Weight	224.61 g/mol
Synonyms	2-Amino-3-chloro-5-(trifluoromethyl)pyridine, N-Ethyl derivative; 3-Chloro-5-(trifluoromethyl)pyridin-2-amine, N-ethyl-; 2-Pyridinamine, 3-chloro-N-ethyl-5-(trifluoromethyl)-; N-Ethyl-3-chloro-5-(trifluoromethyl)pyridin-2-amine; 3-Chloro-N-ethyl-5-(trifluoromethyl)pyridin-2-amine; 1042499-48-8; 3-Chloro-N-ethyl-5-trifluoromethyl-2-pyridinamine
EINECS	Contact for details

Quality Control

Our 3-Chloro-n-Ethyl-5-(Trifluoromethyl)-2-Pyridinamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) documenting purity, impurities, and physical characteristics is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.