Description

1-(Trifluoromethyl)Cyclobutanecarboxylic Acid Ethyl Ester is a high-value fluorinated organic building block. This compound is significant for its unique cyclobutane ring structure combined with a trifluoromethyl group, offering enhanced metabolic stability and lipophilicity for advanced molecular design. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing the metabolically stable trifluoromethyl group.
• Agrochemical Synthesis: Used in creating advanced pesticides and herbicides where the fluorinated cyclobutane moiety can improve biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for specialty polymers and liquid crystals, leveraging the unique electronic properties of the fluorine atoms.
• Organic Synthesis Building Block: Employed in medicinal and combinatorial chemistry for constructing complex, sterically constrained molecular architectures.
• Fluorine Chemistry Studies: Utilized in academic and industrial R&D to explore the effects of fluorinated alicyclic systems on chemical reactivity and physical properties.

Basic Information

Product Name	1-(Trifluoromethyl)Cyclobutanecarboxylic Acid Ethyl Ester
CAS No.	1040683-08-6
Molecular Formula	C8H11F3O2
Molecular Weight	196.17 g/mol
Synonyms	Ethyl 1-(Trifluoromethyl)cyclobutanecarboxylate; 1-(Trifluoromethyl)cyclobutanecarboxylic Acid Ethyl Ester; Cyclobutanecarboxylic acid, 1-(trifluoromethyl)-, ethyl ester; Ethyl 1-(Trifluoromethyl)cyclobutan-1-carboxylate; 1-Trifluoromethyl-cyclobutanecarboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our 1-(Trifluoromethyl)Cyclobutanecarboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatographic purity analysis and identity confirmation, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.