Description

5-Chloro-4-Iodo-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine is a high-value, multi-functionalized heterocyclic building block designed for advanced synthetic chemistry. This compound is critical for medicinal chemistry research and development, serving as a key intermediate in the synthesis of complex molecules targeting various therapeutic areas. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs) and other biologically active compounds.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel drug candidates, particularly in kinase inhibitor research and other targeted therapies.
• Medicinal Chemistry R&D: Used for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Organic Synthesis Reagent: Serves as a versatile scaffold for further functionalization via cross-coupling reactions (e.g., Suzuki, Sonogashira) due to the reactive halogen atoms.
• Agrochemical Research: Potential intermediate in the development of new crop protection agents and pesticides.
• Material Science Precursor: Can be utilized in the synthesis of organic electronic materials and functional dyes.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.

Basic Information

Product Name	5-Chloro-4-Iodo-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	1040682-76-5
Molecular Formula	C17H26ClIN2Si
Molecular Weight	448.84 g/mol
Synonyms	1H-Pyrrolo[2,3-b]pyridine, 5-chloro-4-iodo-1-[(1,1-dimethylethyl)dimethylsilyl]-; 5-Chloro-4-iodo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine; 1-(Triisopropylsilyl)-5-chloro-4-iodo-1H-pyrrolo[2,3-b]pyridine; TIPS-5-Chloro-4-iodo-1H-pyrrolo[2,3-b]pyridine; 5-Chloro-4-iodo-1-(TIPS)-1H-pyrrolo[2,3-b]pyridine; 1040682-76-5
EINECS	Contact for details

Quality Control

Our 5-Chloro-4-Iodo-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, essential for sensitive research applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to meet the stringent requirements of pharmaceutical R&D and cGMP environments where reliable material performance is non-negotiable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.