Description

tert-Butyl (3-Nitropyridin-2-Yl)Carbamate is a high-purity, advanced pharmaceutical intermediate characterized by its nitropyridine core and carbamate protecting group. This compound is of significant value in medicinal chemistry for its role as a versatile building block in the synthesis of complex, nitrogen-containing heterocycles. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new active pharmaceutical ingredients (APIs), particularly for oncology and central nervous system (CNS) targets.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates, especially kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to introduce the nitropyridine moiety into molecular scaffolds.
• Custom Synthesis: Serves as a starting material or intermediate for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.
• Agrochemical Development: Potential application in the research and synthesis of new generation herbicides and pesticides containing functionalized pyridine structures.
• Chemical Biology Probes: Can be utilized to create labeled or tagged molecules for studying biological pathways and target engagement.

Basic Information

Product Name	tert-Butyl (3-Nitropyridin-2-Yl)Carbamate
CAS No.	1040363-53-8
Molecular Formula	C10H13N3O4
Molecular Weight	239.23 g/mol
Synonyms	2-((tert-Butoxycarbonyl)amino)-3-nitropyridine; tert-Butyl N-(3-nitropyridin-2-yl)carbamate; 3-Nitro-2-pyridinylcarbamic acid 1,1-dimethylethyl ester; Boc-3-Nitro-2-aminopyridine; (3-Nitro-pyridin-2-yl)-carbamic acid tert-butyl ester; 2-(Boc-amino)-3-nitropyridine; 2-Amino-3-nitropyridine N-Boc protected
EINECS	Contact for details

Quality Control

Our tert-Butyl (3-Nitropyridin-2-Yl)Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.