Description

Methyl 4,6-Dichloro-5-Methylnicotinate is a high-purity, synthetically valuable nicotinate derivative serving as a critical building block in advanced organic synthesis. Its primary commercial value lies in its role as a key intermediate for the development of complex active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce specific chlorinated pyridine motifs into target molecules.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-infectives, and other therapeutic areas.
• Agrochemical Synthesis: Used in the manufacturing of advanced herbicides, fungicides, and insecticides where the dichloronicotinate scaffold provides key biological activity.
• Fine Chemical Production: Serves as a versatile building block for creating complex molecules used in material science, dyes, and specialty chemicals.
• Research & Development: Employed in academic and industrial R&D laboratories for method development and exploring new chemical entities.
• Custom Synthesis: A starting material for contract manufacturing organizations (CMOs) producing bespoke compounds for client-specific projects.

Basic Information

Product Name	Methyl 4,6-Dichloro-5-Methylnicotinate
CAS No.	1040247-14-0
Molecular Formula	C8H7Cl2NO2
Molecular Weight	220.05 g/mol
Synonyms	Methyl 4,6-dichloro-5-methylpyridine-3-carboxylate; 5-Methylnicotinic acid, 4,6-dichloro-, methyl ester; 3-Pyridinecarboxylic acid, 4,6-dichloro-5-methyl-, methyl ester; 4,6-Dichloro-5-methylnicotinic acid methyl ester; Methyl 4,6-dichloro-5-methyl-3-pyridinecarboxylate
EINECS	Contact for details

Quality Control

Our Methyl 4,6-Dichloro-5-Methylnicotinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound should be handled in accordance with good laboratory and industrial hygiene practices.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.