Description

1-Benzyl-3,3-Difluoropiperidin-4-Amine is a high-purity, advanced pharmaceutical intermediate featuring a unique difluorinated piperidine scaffold. This compound is of significant commercial interest for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular modulation. It is primarily sought by research institutions and pharmaceutical companies engaged in the development of new drugs, agrochemicals, and other fine chemicals where the introduction of fluorine atoms is critical for enhancing metabolic stability and binding affinity.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, where the difluoropiperidine moiety can improve efficacy and environmental profile.
• Chemical Biology Probe: Serves as a versatile scaffold for creating molecular probes to study enzyme function and receptor interactions in biological systems.
• Ligand Synthesis for Catalysis: Employed in the preparation of specialized ligands for asymmetric catalysis and other synthetic transformations.
• Material Science Precursor: Potential use as a monomer or precursor in the synthesis of advanced polymers with specific fluorinated properties.

Basic Information

Product Name	1-Benzyl-3,3-Difluoropiperidin-4-Amine
CAS No.	1039741-55-3
Molecular Formula	C12H16F2N2
Molecular Weight	226.27 g/mol
Synonyms	1-Benzyl-3,3-difluoropiperidin-4-amine; 4-Amino-1-benzyl-3,3-difluoropiperidine; 3,3-Difluoro-1-benzylpiperidin-4-amine; 1-Benzyl-3,3-difluoro-4-piperidinamine; 1039741-55-3; 4-Piperidinamine, 3,3-difluoro-1-(phenylmethyl)-
EINECS	Contact for details

Quality Control

Our 1-Benzyl-3,3-Difluoropiperidin-4-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for advanced intermediates. Our commitment is to deliver material of consistent high purity and reliable supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.