Description

4-Bromo-2-(Tetrahydro-2H-Pyran-4-Yloxy)Pyridine is a high-purity, advanced pharmaceutical intermediate characterized by its bromopyridine core functionalized with a tetrahydropyranyloxy group. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for constructing complex molecular architectures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in kinase inhibitor programs.
• Medicinal Chemistry: Used for structure-activity relationship (SAR) studies and lead optimization due to its modifiable bromine and ether functionalities.
• Agrochemical Synthesis: Serves as a precursor in the development of novel herbicides and fungicides.
• Chemical Biology: Employed in the synthesis of molecular probes and tool compounds for target validation and biochemical assays.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs engaged in custom synthesis projects.
• Academic Research: Used in university and institutional labs for methodological development in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	4-Bromo-2-(Tetrahydro-2H-Pyran-4-Yloxy)Pyridine
CAS No.	1036761-99-5
Molecular Formula	C10H12BrNO2
Molecular Weight	258.11 g/mol
Synonyms	4-Bromo-2-[(Oxan-4-yl)oxy]pyridine; 2-(Tetrahydro-2H-pyran-4-yloxy)-4-bromopyridine; 4-Bromo-2-(tetrahydropyran-4-yloxy)pyridine; 4-Bromo-2-(THP-4-yloxy)pyridine; Pyridine, 4-bromo-2-(tetrahydro-2H-pyran-4-yloxy)-; 1036761-99-5
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-(Tetrahydro-2H-Pyran-4-Yloxy)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat and incompatible materials. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.