Description

n-Methyl-3-(trifluoromethyl)pyridin-2-amine is a high-value, fluorinated pyridine derivative serving as a critical building block in advanced organic synthesis. Its structure, featuring a trifluoromethyl group and a methylated amine, makes it an essential intermediate for creating compounds with enhanced metabolic stability, lipophilicity, and bioavailability. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the trifluoromethyl group can improve compound activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for specialized ligands in catalytic systems or as a structural motif in materials science research.
• Chemical Biology Probe Synthesis: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Fluorinated Building Block: Provides a source of the -CF3 moiety for introducing fluorine atoms into more complex molecular architectures, a common strategy in modern lead optimization.

Basic Information

Product Name	n-Methyl-3-(trifluoromethyl)pyridin-2-amine
CAS No.	1036584-14-1
Molecular Formula	C8H7F3N2
Molecular Weight	188.15 g/mol
Synonyms	2-Amino-N-methyl-3-(trifluoromethyl)pyridine; 3-(Trifluoromethyl)-2-(methylamino)pyridine; N-Methyl-3-trifluoromethylpyridin-2-amine; 2-(Methylamino)-3-(trifluoromethyl)pyridine; 1036584-14-1; 3-Trifluoromethyl-2-methylaminopyridine; Pyridine, 2-(methylamino)-3-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our n-Methyl-3-(trifluoromethyl)pyridin-2-amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment is to supply material that meets the exacting standards required for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.