Description

5-Amino-2-Bromo-4-Fluorobenzoic Acid Methyl Ester is a high-value, multi-functional aromatic building block essential for advanced organic synthesis. Its unique structure, featuring amino, bromo, and fluoro substituents on a benzoate core, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders, oncology, and anti-infective agents.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the fluorine and bromine atoms enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and advanced polymers where its aromatic and halogenated structure imparts specific electronic or physical characteristics.
• Fluorescent Dye and Sensor Fabrication: Acts as a core component for synthesizing novel fluorophores and molecular probes used in bio-imaging and diagnostic applications.
• Custom Synthesis and Contract Manufacturing: A vital building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	5-Amino-2-Bromo-4-Fluorobenzoic Acid Methyl Ester
CAS No.	1036389-86-2
Molecular Formula	C8H7BrFNO2
Molecular Weight	248.05 g/mol
Synonyms	Methyl 5-Amino-2-Bromo-4-Fluorobenzoate; 2-Bromo-4-Fluoro-5-Aminobenzoic Acid Methyl Ester; Benzoic acid, 5-amino-2-bromo-4-fluoro-, methyl ester; 5-Amino-2-bromo-4-fluorobenzoic acid methyl ester; Methyl 5-amino-2-bromo-4-fluorobenzoate; 1036389-86-2; 5-Amino-2-bromo-4-fluorobenzoate methyl ester
EINECS	Contact for details

Quality Control

Every batch of 5-Amino-2-Bromo-4-Fluorobenzoic Acid Methyl Ester is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and commercial synthesis. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC Area %)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.