Description

tert-Butyl 3-Bromo-2-oxo-1,5,7,8-tetrahydro-1,6-naphthyridine-6-carboxylate is a high-purity, advanced pharmaceutical intermediate crucial for modern drug discovery and development. This compound serves as a versatile and reactive building block, enabling the synthesis of complex heterocyclic scaffolds with potential therapeutic applications. It is primarily sought after by research institutions and pharmaceutical companies engaged in medicinal chemistry, particularly for projects targeting central nervous system (CNS) disorders and other disease areas.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of novel active pharmaceutical ingredients (APIs), especially for neurological targets.
• Medicinal Chemistry Research: Used as a core scaffold for constructing diverse compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Organic Synthesis Building Block: The bromo and ester functional groups provide handles for further derivatization via cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and hydrolysis.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable synthesis of complex naphthyridine-based molecules.
• Academic Research: Utilized in universities and research institutes for studying heterocyclic chemistry and developing new synthetic methodologies.

Basic Information

Product Name	tert-Butyl 3-Bromo-2-oxo-1,5,7,8-tetrahydro-1,6-naphthyridine-6-carboxylate
CAS No.	1036381-92-6
Molecular Formula	C₁₃H₁₅BrN₂O₃
Molecular Weight	327.17 g/mol
Synonyms	1,6-Naphthyridine-6-carboxylic acid, 3-bromo-1,5,7,8-tetrahydro-2-oxo-, 1,1-dimethylethyl ester; 6-(tert-Butoxycarbonyl)-3-bromo-1,5,7,8-tetrahydro-1,6-naphthyridin-2-one; 3-Bromo-6-(tert-butoxycarbonyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2(1H)-one; tert-Butyl 3-bromo-2-oxo-5,6,7,8-tetrahydro-1,6-naphthyridine-6(1H)-carboxylate; BOC-3-Bromo-1,6-naphthyridinone
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-Bromo-2-oxo-1,5,7,8-tetrahydro-1,6-naphthyridine-6-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.