Description

5-(Trifluoromethyl)-3-((Trimethylsilyl)Ethynyl)-Pyridin-2-Amine CAS NO 1036027-52-7 is a high-value, multi-functional pyridine derivative featuring both a trifluoromethyl group and a trimethylsilyl-protected alkyne moiety. This unique structure makes it a critical advanced pharmaceutical intermediate (API) and a versatile building block for medicinal chemistry and materials science research. It is primarily sought after by R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical sectors for developing novel active compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Medicinal Chemistry Building Block: Used in high-throughput screening and structure-activity relationship (SAR) studies to introduce both lipophilic (CF3) and reactive alkyne handles for further functionalization via click chemistry.
• Agrochemical Synthesis: Serves as a core structure for developing new generation herbicides, fungicides, and insecticides with improved efficacy and environmental profile.
• Material Science Research: Employed in the creation of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its electron-withdrawing and conjugation-modifying properties.
• Ligand and Catalyst Development: Used to synthesize novel ligands for transition metal catalysis and organocatalysts, leveraging the pyridine nitrogen and alkyne functionality.
• Fluorine Chemistry: Acts as a valuable source of the trifluoromethyl group for introducing fluorine atoms into target molecules to enhance metabolic stability, bioavailability, and membrane permeability.

Basic Information

Product Name	5-(Trifluoromethyl)-3-((Trimethylsilyl)Ethynyl)-Pyridin-2-Amine
CAS No.	1036027-52-7
Molecular Formula	C11H13F3N2Si
Molecular Weight	258.32 g/mol
Synonyms	2-Amino-5-(trifluoromethyl)-3-[(trimethylsilyl)ethynyl]pyridine; 3-((Trimethylsilyl)ethynyl)-5-(trifluoromethyl)pyridin-2-amine; 5-(Trifluoromethyl)-3-(2-trimethylsilylethynyl)pyridin-2-amine; 2-Pyridinamine, 5-(trifluoromethyl)-3-[(trimethylsilyl)ethynyl]-; TMS-Ethynyl-CF3-Pyridinamine; 1036027-52-7; 5-Trifluoromethyl-3-trimethylsilylethynyl-pyridin-2-ylamine
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethyl)-3-((Trimethylsilyl)Ethynyl)-Pyridin-2-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.