Description

2-Chloro-5-Cyclopropyl-Nicotinic Acid is a high-value pyridinecarboxylic acid derivative, serving as a critical building block in modern organic synthesis. Its unique structure, featuring both chloro and cyclopropyl substituents, makes it an indispensable intermediate for constructing complex molecules with targeted biological activity. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drug candidates targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and fungicides, leveraging the bioactivity of the cyclopropyl-nicotinic acid scaffold.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in catalytic processes and metal-organic frameworks (MOFs).
• Chemical Research: A versatile building block for medicinal chemistry and process chemistry, enabling structure-activity relationship (SAR) studies and route scouting.
• Fine Chemical Production: Employed in the multi-step synthesis of other high-value, functionalized nicotinic acid derivatives.

Basic Information

Product Name	2-Chloro-5-Cyclopropyl-Nicotinic Acid
CAS No.	1035690-32-4
Molecular Formula	C9H8ClNO2
Molecular Weight	197.62 g/mol
Synonyms	2-Chloro-5-cyclopropylpyridine-3-carboxylic acid; 5-Cyclopropyl-2-chloronicotinic acid; 3-Pyridinecarboxylic acid, 2-chloro-5-cyclopropyl-; 2-Chloro-5-cyclopropyl-3-pyridinecarboxylic acid; 1035690-32-4 (CAS); 2-Chloro-5-cyclopropylnicotinic acid
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Cyclopropyl-Nicotinic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and scale-up applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for full traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.