Description

5-Cyclopropyl-2-Fluoro-3-Iodopyridine is a high-value, multi-functional halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring cyclopropyl, fluoro, and iodo substituents, makes it an indispensable intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, infectious diseases, and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the halogenated pyridine core.
• Material Science Research: Serves as a building block for creating functional organic materials, such as liquid crystals, organic semiconductors, and metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: The iodine atom at the 3-position makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Sonogashira) to introduce complex aryl or alkynyl groups.
• Medicinal Chemistry Library Development: Employed in high-throughput synthesis to generate diverse compound libraries for screening against novel biological targets.
• Fluorine Chemistry: The fluorine atom provides metabolic stability and influences lipophilicity, making it valuable for structure-activity relationship (SAR) studies in drug discovery.

Basic Information

Item	Detail
Product Name	5-Cyclopropyl-2-Fluoro-3-Iodopyridine
CAS No.	1034467-82-7
Molecular Formula	C8H7F I N
Molecular Weight	263.05 g/mol
Synonyms	3-Iodo-5-cyclopropyl-2-fluoropyridine; 2-Fluoro-3-iodo-5-cyclopropylpyridine; 5-Cyclopropyl-2-fluoro-3-iodopyridine; 2-Fluoro-5-cyclopropyl-3-iodopyridine; 1034467-82-7 (CAS Name); Pyridine, 5-cyclopropyl-2-fluoro-3-iodo-
EINECS	Contact for details

Quality Control

Every batch of 5-Cyclopropyl-2-Fluoro-3-Iodopyridine is manufactured and tested under a strict quality management system. We guarantee high chemical purity and lot-to-lot consistency, which is critical for reproducible research and process development. Our products undergo rigorous quality testing, including HPLC, NMR, and GC-MS analysis, to ensure compliance with industry standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.