Description

4-Chloro-3-((Trimethylsilyl)ethynyl)pyridine is a high-value organosilicon building block featuring a pyridine core functionalized with both a chloro substituent and a trimethylsilyl-protected acetylene group. This compound is critical for advanced organic synthesis, enabling efficient cross-coupling reactions and serving as a versatile precursor for complex heterocyclic systems. It is primarily utilized by pharmaceutical and agrochemical R&D teams, as well as by manufacturers of specialty materials and liquid crystals, for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides due to its functionalized heterocyclic structure.
• Material Science: Serves as a precursor for organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) requiring tailored electronic properties.
• Cross-Coupling Reactions: The chloro and ethynyl groups make it an excellent substrate for Sonogashira, Suzuki-Miyaura, and other palladium-catalyzed couplings.
• Chemical Synthesis: Used as a protected alkyne building block in multi-step organic synthesis, where the TMS group can be readily deprotected.
• Ligand Synthesis: Employed in the preparation of novel nitrogen-containing ligands for catalysis and coordination chemistry.

Basic Information

Product Name	4-Chloro-3-((Trimethylsilyl)ethynyl)pyridine
CAS No.	1034467-33-8
Molecular Formula	C10H12ClNSi
Molecular Weight	209.75 g/mol
Synonyms	4-Chloro-3-[(trimethylsilyl)ethynyl]pyridine; 3-((Trimethylsilyl)ethynyl)-4-chloropyridine; 4-Chloro-3-(2-trimethylsilylethynyl)pyridine; Pyridine, 4-chloro-3-[(trimethylsilyl)ethynyl]-; 1034467-33-8; 4-Chloro-3-(trimethylsilylethynyl)pyridine
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-((Trimethylsilyl)ethynyl)pyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications and supporting regulatory filings for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.