Description

Methyl 5-((tert-Butoxycarbonyl)(Methyl)Amino)-2-Chloroisonicotinate is a high-purity, advanced pharmaceutical intermediate featuring a protected amine and a reactive chloro-substituent on a pyridine core. This compound is critical for the synthesis of complex molecules, particularly in medicinal chemistry for the development of active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting neurological and oncological pathways.
• API Synthesis: Used in the multi-step preparation of complex Active Pharmaceutical Ingredients (APIs) where a protected amino-chloropyridine moiety is required.
• Medicinal Chemistry Research: Serves as a versatile scaffold in structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Biology Probes: Employed in the development of chemical probes and tool compounds for biological target validation.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing specialized fine chemicals.

Basic Information

Product Name	Methyl 5-((tert-Butoxycarbonyl)(Methyl)Amino)-2-Chloroisonicotinate
CAS No.	1034131-89-9
Molecular Formula	C13H17ClN2O4
Molecular Weight	300.74 g/mol
Synonyms	Methyl 5-[(tert-butoxycarbonyl)(methyl)amino]-2-chloropyridine-4-carboxylate; 2-Chloro-5-[(N-methyl-N-Boc)amino]isonicotinic acid methyl ester; 5-((tert-Butoxycarbonyl)(methyl)amino)-2-chloroisonicotinic acid methyl ester; Methyl 2-chloro-5-[(N-methyl-N-Boc)amino]isonicotinate; 4-Pyridinecarboxylic acid, 2-chloro-5-[[(1,1-dimethylethoxy)carbonyl]methylamino]-, methyl ester; Boc-Me-Amino-2-Cl-isonicotinate methyl ester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is analyzed to confirm identity, purity, and impurity profile using advanced analytical techniques. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to ensure full traceability and support your quality management systems.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.