Description

5-Iodo-Nicotinic Acid Methyl Ester is a halogenated nicotinic acid derivative that serves as a versatile and high-value synthetic intermediate. This compound is particularly significant for its role in constructing complex molecular architectures in pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for applications such as Suzuki-Miyaura cross-coupling reactions and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the bioactivity of the nicotinic acid scaffold.
• Cross-Coupling Reactions: Serves as a crucial electrophilic partner in palladium-catalyzed cross-coupling reactions, such as Suzuki, Stille, and Sonogashira couplings, to form biaryl and other complex structures.
• Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and material science applications.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and protein interactions.
• Advanced Material Precursor: Acts as a monomer or functionalizing agent in the synthesis of organic electronic materials and liquid crystals.

Basic Information

Product Name	5-Iodo-Nicotinic Acid Methyl Ester
CAS No.	1033955-80-4
Molecular Formula	C7H6INO2
Molecular Weight	263.04 g/mol
Synonyms	Methyl 5-iodonicotinate; 5-Iodopyridine-3-carboxylic acid methyl ester; 3-Pyridinecarboxylic acid, 5-iodo-, methyl ester; 5-Iodo-3-pyridinecarboxylic acid methyl ester; Methyl 5-iodo-3-pyridinecarboxylate; 5-Iodo-3-(methoxycarbonyl)pyridine; 5-Iodonicotinic acid methyl ester
EINECS	Contact for details

Quality Control

Our 5-Iodo-Nicotinic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.