Description

2,2-Difluoroethanesulfonyl Chloride is a specialized organofluorine building block and sulfonylating agent of significant interest in advanced chemical synthesis. Its value lies in its ability to introduce the highly reactive sulfonyl chloride group adjacent to a difluoromethylene unit, enabling the construction of complex, fluorinated molecules with tailored properties. This compound is primarily needed by research and development chemists and process scale-up teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key reagent for synthesizing sulfonamide-based drug candidates, including protease inhibitors and kinase inhibitors.
• Agrochemical Synthesis: Used in the development of new herbicides and pesticides where the fluorine atoms enhance biological activity and environmental stability.
• Material Science: Building block for creating fluorinated polymers and surfactants with unique surface properties and chemical resistance.
• Chemical Biology: Employed in the synthesis of activity-based probes and covalent inhibitors for target identification and validation studies.
• Custom Synthesis & Contract Manufacturing: Serves as a critical starting material for custom fluorination and sulfonylation projects at various scales.

Basic Information

Product Name	2,2-Difluoroethanesulfonyl Chloride
CAS No.	1033906-60-3
Molecular Formula	C2H2ClF2O2S
Molecular Weight	162.55 g/mol
Synonyms	2,2-Difluoroethanesulfonyl chloride; 2,2-Difluoroethane-1-sulfonyl chloride; 1-Chlorosulfonyl-2,2-difluoroethane; Ethanesulfonyl chloride, 2,2-difluoro-; 2,2-Difluoroethylsulfonyl chloride; DFESC; 1033906-60-3
EINECS	Contact for details

Quality Control

Every batch of 2,2-Difluoroethanesulfonyl Chloride is produced and tested under strict quality management protocols to ensure high purity and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.