Description

2,2-Difluoroethanesulfonamide is a high-purity, specialized organofluorine building block of significant interest in advanced chemical synthesis. Its value lies in the unique reactivity imparted by the sulfonamide and difluoroalkyl groups, enabling precise molecular modifications. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting enzyme inhibition.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity and stability.
• Material Science Research: Serves as a precursor for functional materials, including specialty polymers and liquid crystals, where sulfonamide groups can modify material properties.
• Chemical Biology Probe Development: Employed in the synthesis of labeled compounds and probes for studying biological mechanisms and pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses serving the life sciences sector with tailored, complex molecules.

Basic Information

Product Name	2,2-Difluoroethanesulfonamide
CAS No.	1033906-56-7
Molecular Formula	C₂H₅F₂NO₂S
Molecular Weight	145.13 g/mol
Synonyms	2,2-Difluoroethanesulfonic acid amide; 2,2-Difluoroethane-1-sulfonamide; α,α-Difluoroethanesulfonamide; Ethanesulfonamide, 2,2-difluoro-; 1,1-Difluoro-2-sulfamoylethane; DFESA; 1033906-56-7 (CAS)
EINECS	Contact for details

Quality Control

Every batch of 2,2-Difluoroethanesulfonamide is produced and tested under a strict quality management system. We ensure high chemical purity and lot-to-lot consistency through advanced analytical techniques including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.