Description

3-Pyridinecarboxamide, 6-(3-Fluorophenyl)-n-[1-(2,2,2-Trifluoroethyl)-4-Piperidinyl]- is a high-purity, advanced pharmaceutical intermediate designed for research and development. This compound is critical for medicinal chemists exploring novel therapeutic agents, particularly within the central nervous system (CNS) and oncology fields. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers requiring a reliable supply of complex, fluorinated heterocyclic building blocks.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the development of new active pharmaceutical ingredients (APIs), especially for CNS-targeting drugs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its unique fluorinated piperidine-pyridine scaffold.
• Kinase Inhibitor Development: A potential building block for the synthesis of small molecule kinase inhibitors, a major class in oncology and inflammatory disease therapeutics.
• Chemical Biology Probes: Employed in the creation of specialized probes for studying biological pathways and target engagement.
• Custom Synthesis: Used by contract research and manufacturing organizations (CROs/CMOs) for client-specific custom synthesis projects.

Basic Information

Product Name	3-Pyridinecarboxamide, 6-(3-Fluorophenyl)-n-[1-(2,2,2-Trifluoroethyl)-4-Piperidinyl]-
CAS No.	1033836-12-2
Molecular Formula	C19H17F4N3O
Molecular Weight	379.35 g/mol
Synonyms	6-(3-Fluorophenyl)-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]nicotinamide; 1033836-12-2; 6-(3-Fluorophenyl)-N-[1-(2,2,2-trifluoroethyl)-4-piperidinyl]-3-pyridinecarboxamide; Nicotinamide, 6-(3-fluorophenyl)-N-[1-(2,2,2-trifluoroethyl)-4-piperidinyl]-; 6-(3-Fluorophenyl)-N-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)pyridine-3-carboxamide
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with client specifications. We support development from milligram to kilogram scale with traceable documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.