Description

3-(4-Boc-Piperazin-1-Ylsulfonyl)Phenylboronic Acid Pinacol Ester is a sophisticated boronic ester derivative designed for advanced synthetic chemistry, particularly in pharmaceutical research and development. This compound serves as a key protected intermediate, enabling the controlled introduction of a functionalized phenylboronic acid moiety into complex molecular architectures. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of novel active pharmaceutical ingredients (APIs) and chemical probes.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of drug candidates, especially those targeting kinases and other enzymes where the piperazine-sulfonyl-phenylboronate motif is pharmacologically relevant.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a stable, protected boronic ester reagent for palladium-catalyzed cross-coupling to form biaryl and heterobiaryl structures, which are common scaffolds in medicinal chemistry.
• Proteolysis Targeting Chimera (PROTAC) Development: Used in the construction of bifunctional molecules where one end binds to a target protein and the other recruits an E3 ubiquitin ligase.
• Chemical Biology Probe Synthesis: Employed to create tagged or labeled molecules for studying biological pathways and protein function.
• Peptide and Protein Conjugation: The boronic acid ester, after deprotection, can be used for selective conjugation chemistries with diols and other functional groups.
• Material Science Research: Potential use as a monomer or functionalizing agent in the synthesis of advanced organic polymers and frameworks.

Basic Information

Product Name	3-(4-Boc-Piperazin-1-Ylsulfonyl)Phenylboronic Acid Pinacol Ester
CAS No.	1033743-83-7
Molecular Formula	C21H33BN2O6S
Molecular Weight	452.37 g/mol
Synonyms	3-(4-(tert-Butoxycarbonyl)piperazin-1-ylsulfonyl)phenylboronic acid pinacol ester; 1-Boc-4-[(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)sulfonyl]piperazine; tert-Butyl 4-{[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]sulfonyl}piperazine-1-carboxylate; 3-(N-Boc-piperazinylsulfonyl)phenylboronic acid pinacol ester; Boc-Piperazine-Sulfonyl-Phenyl-Bpin; 3-(1-Boc-4-piperazinylsulfonyl)benzeneboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 3-(4-Boc-Piperazin-1-Ylsulfonyl)Phenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a controlled, dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95.0% (Area %)
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.