Description

6-[4-(Trifluoromethyl)Piperidino]Nicotinic Acid is a high-value, functionalized nicotinic acid derivative featuring a trifluoromethyl-substituted piperidine moiety, making it a critical building block in modern synthetic chemistry. Its core value lies in its unique structure, which combines the metabolic activity of nicotinic acid with the enhanced lipophilicity, metabolic stability, and bioavailability imparted by the trifluoromethyl group. This compound is primarily sought after by pharmaceutical R&D and agrochemical manufacturers for the development of novel active ingredients, including kinase inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key synthetic precursor for the development of novel drug candidates, particularly in oncology and metabolic disease research.
• Kinase Inhibitor Scaffold: Used in the synthesis of potent and selective kinase inhibitors due to its ability to act as a hinge-binding motif or a core structural element.
• Agrochemical Research: Serves as a building block for creating new active ingredients with improved pest control efficacy and environmental profiles.
• Chemical Biology Probe Synthesis: Employed in the design and synthesis of molecular probes for studying biological pathways and target validation.
• Material Science: Potential monomer or additive for advanced polymers where fluorine incorporation is desired for specific material properties.

Basic Information

Product Name	6-[4-(Trifluoromethyl)Piperidino]Nicotinic Acid
CAS No.	1033463-36-3
Molecular Formula	C12H13F3N2O2
Molecular Weight	274.24 g/mol
Synonyms	6-[4-(Trifluoromethyl)piperidin-1-yl]pyridine-3-carboxylic acid; 6-(4-Trifluoromethyl-1-piperidinyl)nicotinic acid; 3-Pyridinecarboxylic acid, 6-[4-(trifluoromethyl)-1-piperidinyl]-; 6-(4-(Trifluoromethyl)piperidin-1-yl)nicotinic acid; 1-(5-Carboxypyridin-2-yl)-4-(trifluoromethyl)piperidine; 6-(4-Trifluoromethylpiperidino)nicotinic acid
EINECS	Contact for details

Quality Control

Our 6-[4-(Trifluoromethyl)Piperidino]Nicotinic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), residual solvents, and other critical parameters is provided with every shipment to guarantee traceability and reliability for your projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.