Description

2-Bromo-4-Chloro-5-Fluoropyridine is a high-value, multi-halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. This compound matters for its unique reactivity profile, enabling the precise introduction of halogen substituents which are pivotal for modulating the biological activity and physicochemical properties of target molecules. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients, particularly in creating novel heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, especially for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides where the halogenated pyridine core contributes to efficacy and environmental profile.
• Material Science Research: Serves as a precursor for functionalized ligands and organic electronic materials due to its halogen handles for further cross-coupling reactions.
• Chemical Biology Probes: Employed in the synthesis of tagged molecules for studying biological pathways and target engagement.
• Cross-Coupling Reactions: The bromo and chloro groups are excellent substrates for Suzuki, Stille, and Buchwald-Hartwig amination reactions to build complex molecular architectures.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects requiring specific halogen substitution patterns on the pyridine ring.

Basic Information

Product Name	2-Bromo-4-Chloro-5-Fluoropyridine
CAS No.	1033203-44-9
Molecular Formula	C5H2BrClFN
Molecular Weight	210.43 g/mol
Synonyms	5-Fluoro-2-bromo-4-chloropyridine; 4-Chloro-5-fluoro-2-bromopyridine; 2-Bromo-4-chloro-5-fluoropyridine; Pyridine, 2-bromo-4-chloro-5-fluoro-; Bromochlorofluoropyridine
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-Chloro-5-Fluoropyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and traceability for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.