Description

2-Bromo-4,5-difluoropyridine is a high-purity, multi-functional halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of bromine and fluorine atoms on the pyridine ring, enabling precise cross-coupling reactions and facilitating the introduction of fluorinated motifs into complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing fluorinated pyridine cores into drug candidates to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoropyridine moiety contributes to improved efficacy and environmental profile.
• Material Science: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and electronic materials requiring specific halogenated aromatic structures.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for Suzuki, Stille, and Buchwald-Hartwig amination reactions, enabling rapid diversification of the molecular scaffold.
• Fluorine Chemistry Research: An important reagent for studying the effects of fluorine substitution on aromatic systems and for synthesizing fluorinated analogs of biologically active compounds.
• Ligand and Catalyst Development: Utilized in the preparation of novel nitrogen-containing ligands for transition metal catalysis.

Basic Information

Product Name	2-Bromo-4,5-difluoropyridine
CAS No.	1033203-43-8
Molecular Formula	C5H2BrF2N
Molecular Weight	193.98 g/mol
Synonyms	4,5-Difluoro-2-bromopyridine; 2-Bromo-4,5-difluoropyridine; Pyridine, 2-bromo-4,5-difluoro-; 1033203-43-8; 2-Bromo-4,5-difluoro-pyridine; 4,5-Difluoro-2-bromo-pyridine; BRD-K94212522
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-4,5-difluoropyridine is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure it meets the high standards required for research and commercial synthesis. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment ensures reliable performance in your most sensitive coupling and fluorination reactions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Melting Point	Contact for details
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.