Description

1H-Pyrrolo[2,3-B]Pyridine, 4-Chloro-5-(1,3-Dioxolan-2-Yl)-1-(Phenylsulfonyl)- is a high-purity, advanced pharmaceutical intermediate characterized by its unique fused heterocyclic structure. This compound is of significant commercial importance for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor research. It is primarily needed by R&D laboratories, process development chemists, and manufacturers in the pharmaceutical and biotechnology industries engaged in developing targeted therapies for oncology and other disease areas.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates, especially kinase inhibitors.
• Organic Synthesis Building Block: Used in medicinal chemistry for constructing fused heterocyclic scaffolds with potential biological activity.
• Research & Development (R&D): Essential for academic and industrial research programs focused on discovering new chemical entities (NCEs).
• Process Chemistry & Scale-Up: Serves as a starting material for optimizing synthetic routes from milligram to kilogram scale for clinical trials.
• Contract Manufacturing (CMO/CDMO): Supplied to contract research and manufacturing organizations supporting global drug development pipelines.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 4-Chloro-5-(1,3-Dioxolan-2-Yl)-1-(Phenylsulfonyl)-
CAS No.	1032815-08-9
Molecular Formula	C16H13ClN2O4S
Molecular Weight	364.80 g/mol
Synonyms	4-Chloro-5-(1,3-dioxolan-2-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1-(Phenylsulfonyl)-4-chloro-5-(1,3-dioxolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; 4-Chloro-5-(1,3-dioxolan-2-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine (common alias); 1032815-08-9; 1H-Pyrrolo[2,3-b]pyridine, 4-chloro-5-(1,3-dioxolan-2-yl)-1-(phenylsulfonyl)-; 4-Chloro-1-(phenylsulfonyl)-5-(1,3-dioxolan-2-yl)-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems to ensure batch-to-batch consistency and reliability for critical R&D and scale-up work. Every lot undergoes comprehensive analytical characterization using techniques including HPLC, NMR, and MS to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support compliance with cGMP standards for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.