Description

6-(tert-Butyloxycarbonyl-Methylamino)-5-Methylpyridine-3-Boronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate featuring a protected amine and a boronic ester functional group. This compound is critical for enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which is fundamental to modern medicinal chemistry and drug discovery. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those targeting neurological and oncological pathways.
• Suzuki-Miyaura Cross-Coupling: The boronic ester moiety serves as a crucial coupling partner for forming carbon-carbon bonds between aromatic rings, a cornerstone of modern synthetic chemistry.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Chemical Biology Probes: Can be utilized to create labeled molecules for studying biological mechanisms and target engagement.
• Agrochemical Synthesis: Potential intermediate in the development of novel pesticides or herbicides requiring specific pyridine-based architectures.

Basic Information

Product Name	6-(tert-Butyloxycarbonyl-Methylamino)-5-Methylpyridine-3-Boronic Acid Pinacol Ester
CAS No.	1032758-82-9
Molecular Formula	C18H29BN2O4
Molecular Weight	348.25 g/mol
Synonyms	5-Methyl-6-[(2-methylpropan-2-yl)oxycarbonyl(methyl)amino]pyridine-3-boronic acid pinacol ester; tert-Butyl N-methyl-N-(5-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)carbamate; Boc-N(Me)-5-Methylpyridin-3-yl-Bpin; 3-Borono-5-methyl-6-[(N-methyl-N-Boc)amino]pyridine pinacol ester; 6-(Boc-Methylamino)-5-Methylpyridine-3-Boronic Acid Pinacol Ester; CAS 1032758-82-9; (5-Methyl-6-((N-methyl-tert-butoxycarbonyl)amino)pyridin-3-yl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 6-(tert-Butyloxycarbonyl-Methylamino)-5-Methylpyridine-3-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.