Description

3-Chloro-2-Fluorophenyl-Isocyanide is a versatile aromatic isocyanide building block essential for modern synthetic chemistry. This high-purity intermediate is critical for constructing complex molecular architectures, particularly in the development of novel pharmaceuticals and advanced materials. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in metal-catalyzed coupling reactions and multicomponent synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of bioactive molecules, heterocycles, and potential drug candidates via multicomponent reactions (MCRs) like the Ugi and Passerini reactions.
• Agrochemical Research: Used in the development of novel pesticides and herbicides, leveraging its reactivity to create diverse chemical scaffolds.
• Material Science: Employed in the synthesis of functionalized polymers, ligands for catalysis, and metal-organic frameworks (MOFs).
• Catalyst & Ligand Synthesis: Serves as a building block for creating novel isocyanide-based ligands used in transition metal catalysis.
• Chemical Biology: Utilized as a probe or tag in bioorthogonal chemistry and activity-based protein profiling due to the unique reactivity of the isocyanide group.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic synthesis and discovery chemistry.

Basic Information

Product Name	3-Chloro-2-Fluorophenyl-Isocyanide
CAS No.	1030269-27-2
Molecular Formula	C7H3ClFNO
Molecular Weight	155.55 g/mol
Synonyms	1-Chloro-2-fluoro-3-isocyanobenzene; 2-Fluoro-3-chlorophenyl isocyanide; 3-Chloro-2-fluorophenyl isocyanide; 3-Chloro-2-fluorobenzene isocyanide; 3-Chloro-2-fluorophenyl isonitrile; Isocyanic acid, 3-chloro-2-fluorophenyl ester; (3-Chloro-2-fluorophenyl)isocyanide
EINECS	Contact for details

Quality Control

Our 3-Chloro-2-Fluorophenyl-Isocyanide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures material consistency and reliability for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.