Description

4-[Isocyano-(Toluene-4-Sulfonyl)-Methyl]-Biphenyl is a specialized organic building block featuring a unique isocyano and tosylmethyl functional group architecture. This compound matters as a versatile intermediate for constructing complex molecular frameworks, particularly in advanced pharmaceutical and materials science research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in medicinal chemistry and catalyst ligand synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in kinase inhibitor and other small-molecule drug discovery programs.
• Agrochemical Research: Used in the development of new generation herbicides, fungicides, and plant growth regulators requiring complex biphenyl structures.
• Ligand Synthesis: Serves as a precursor for creating sophisticated ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science: Intermediate in the production of advanced organic electronic materials, such as OLED (Organic Light-Emitting Diode) components and conductive polymers.
• Chemical Biology Probes: Utilized in the design and synthesis of chemical probes for studying enzyme function and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	4-[Isocyano-(Toluene-4-Sulfonyl)-Methyl]-Biphenyl
CAS No.	1029104-40-2
Molecular Formula	C21H17NO2S
Molecular Weight	347.43 g/mol
Synonyms	4-[(Isocyanomethyl)sulfonyl]methylbiphenyl; 4-[(Tosyl)isocyanomethyl]biphenyl; [1,1'-Biphenyl]-4-methanol, α-isocyano-4-methylbenzenesulfonate; 4-(Isocyanotoluene-4-sulfonylmethyl)biphenyl; TosMIC Biphenyl Derivative; Biphenyl-4-yl(tosyl)methyl isocyanide; p-Toluenesulfonylmethyl isocyanide biphenyl derivative
EINECS	Contact for details

Quality Control

Our 4-[Isocyano-(Toluene-4-Sulfonyl)-Methyl]-Biphenyl is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry place. This material is hygroscopic (moisture-sensitive) and easily oxidized; therefore, containers must be kept tightly sealed and flushed with inert gas after each opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.