Description

o-(tert-Butyldimethylsilyl)-n-Tosylhydroxylamine is a specialized organosilicon reagent featuring a protected hydroxylamine functional group. This compound is a critical building block in organic synthesis, valued for its role as a versatile nitrogen source and protecting group. It is primarily used by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the synthesis of complex molecules.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for the controlled introduction of nitrogen functionalities, such as in the synthesis of amine derivatives, oximes, and nitrones.
• Peptide and Protein Modification: Used in the selective modification of amino acids and the synthesis of unnatural amino acid analogs.
• Polymer Chemistry: Acts as a functional monomer or initiator in the development of specialty polymers with tailored surface properties.
• Agrochemical Research: Employed in the discovery and development of novel active ingredients, including herbicides and fungicides.
• Material Science: Utilized in surface functionalization and the creation of silicon-based hybrid materials.
• Cross-Coupling Reactions: Serves as an amination agent in metal-catalyzed cross-coupling reactions to form C-N bonds.

Basic Information

Product Name	o-(tert-Butyldimethylsilyl)-n-Tosylhydroxylamine
CAS No.	1028432-04-3
Molecular Formula	C₁₃H₂₃NO₃SSi
Molecular Weight	301.48 g/mol
Synonyms	N-[(1,1-Dimethylethyl)dimethylsilyl]oxy]-4-methylbenzenesulfonamide; O-TBDMS-N-tosylhydroxylamine; N-(tert-Butyldimethylsilyloxy)-p-toluenesulfonamide; TBDMS-protected tosylhydroxylamine; O-(tert-Butyldimethylsilyl)-N-(p-tolylsulfonyl)hydroxylamine; N-Tosyl-O-(tert-butyldimethylsilyl)hydroxylamine; TBDMS-OTsNHOH
EINECS	Contact for details

Quality Control

Our o-(tert-Butyldimethylsilyl)-n-Tosylhydroxylamine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.