Description

1,2-Pyrrolidinedicarboxylic Acid, 4-[(7-Chloro-4-Methoxy-1-Isoquinolinyl)Oxy]-, 1-(1,1-Dimethylethyl) Ester, (2S,4R)- is a high-purity, stereochemically defined synthetic intermediate of significant importance in advanced pharmaceutical research and development. This compound is specifically designed for use as a key building block in the synthesis of complex, biologically active molecules, particularly protease inhibitors and other targeted therapeutics. It is essential for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries who require reliable, high-quality intermediates to accelerate drug discovery pipelines and ensure reproducible synthesis.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel drug candidates, particularly in the development of protease inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to explore new chemical entities.
• Process Chemistry & Scale-Up: Serves as a defined starting material or intermediate in the development of robust, scalable synthetic routes for Active Pharmaceutical Ingredients (APIs).
• Biochemical Tool Compound: Potential use in the development of enzyme assays and probes for studying specific biological pathways.
• Custom Synthesis: A foundational component for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.

Basic Information

Product Name	1,2-Pyrrolidinedicarboxylic Acid, 4-[(7-Chloro-4-Methoxy-1-Isoquinolinyl)Oxy]-, 1-(1,1-Dimethylethyl) Ester, (2S,4R)-
CAS No.	1028252-15-4
Molecular Formula	C22H25ClN2O5
Molecular Weight	432.90 g/mol
Synonyms	(2S,4R)-1-(tert-Butyl) 4-[(7-chloro-4-methoxyisoquinolin-1-yl)oxy]pyrrolidine-1,2-dicarboxylate; tert-Butyl (2S,4R)-4-[(7-chloro-4-methoxy-1-isoquinolinyl)oxy]-1,2-pyrrolidinedicarboxylate; (2S,4R)-1-Boc-4-((7-chloro-4-methoxyisoquinolin-1-yl)oxy)pyrrolidine-2-carboxylic acid; 1028252-15-4; A chiral pyrrolidine isoquinoline derivative
EINECS	Contact for details

Quality Control

This product is manufactured under strict quality control protocols to ensure it meets the exacting standards required for pharmaceutical R&D. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and MS to confirm identity, chiral purity, and chemical purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. Our quality system is designed to support regulatory filings, and we can supply materials suitable for use under cGMP guidelines for non-clinical development stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.