Description

3-(Bromomethyl)-1H-Pyrazolo[3,4-B]Pyridine is a versatile and high-value brominated heterocyclic building block. This compound is critical for medicinal chemistry research and pharmaceutical development, serving as a key intermediate in the synthesis of targeted small molecule therapeutics. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors. Its reactive bromomethyl group enables efficient functionalization, making it a pivotal scaffold for constructing novel chemical entities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of kinase inhibitors and other targeted therapeutic agents.
• Medicinal Chemistry Research: Used in hit-to-lead optimization and scaffold hopping strategies for drug discovery programs.
• Agrochemical Development: Intermediate in the creation of novel fungicides or herbicides with specific mode-of-action.
• Chemical Biology Probes: Synthesis of activity-based probes or molecular tags for studying biological pathways.
• Material Science: Potential precursor for organic electronic materials or metal-organic frameworks (MOFs).
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of client-specific advanced intermediates.

Basic Information

Item	Details
Product Name	3-(Bromomethyl)-1H-Pyrazolo[3,4-B]Pyridine
CAS No.	1027990-21-1
Molecular Formula	C8H6BrN3
Molecular Weight	224.06 g/mol
Synonyms	1H-Pyrazolo[3,4-b]pyridine, 3-(bromomethyl)-; 3-(Bromomethyl)-1H-pyrazolo[3,4-b]pyridine; 3-Bromomethyl-1H-pyrazolo[3,4-b]pyridine; 1H-Pyrazolo[3,4-b]pyridine-3-methanol, 3-bromo-; 3-(Bromomethyl)-7-azaindole; 3-Bromomethyl-7-azaindole; 7-Azaindole-3-methanol, 3-bromo-; 1027990-21-1
EINECS	Contact for details

Quality Control

Every batch of 3-(Bromomethyl)-1H-Pyrazolo[3,4-B]Pyridine is produced under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for advanced research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We support development with custom purity grades and specifications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.