Description

1H-Pyrrolo[2,3-B]Pyridine-5-Carboxylic Acid, 2-Cyclopropyl- is a high-purity, heterocyclic carboxylic acid building block of significant interest in advanced organic synthesis. This compound matters for its role as a critical intermediate in the development of novel, small-molecule pharmaceuticals, particularly those targeting kinase inhibition. Pharmaceutical R&D departments and fine chemical manufacturers need this material to construct complex molecular architectures for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitor candidates.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR).
• Chemical Biology Probes: Serves as a core scaffold for developing tool compounds to study biological pathways and target validation.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects.
• Agrochemical Research: Potential intermediate in the discovery of new crop protection agents with novel modes of action.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine-5-Carboxylic Acid, 2-Cyclopropyl-
CAS No.	1027785-15-4
Molecular Formula	C11H10N2O2
Molecular Weight	202.21 g/mol
Synonyms	2-Cyclopropyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid; 2-Cyclopropyl-7-azaindole-5-carboxylic acid; 2-Cyclopropyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid; 2-Cyclopropyl-7-aza-indole-5-carboxylic acid; 2-Cyclopropyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid; 2-Cyclopropyl-7-azaindole-5-carboxylic acid; 2-Cyclopropyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine-5-Carboxylic Acid, 2-Cyclopropyl- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with full traceability are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.