Description

Ethyl-2,2-Difluoro-2-(4-tert-Butylphenyl)Acetate is a high-value fluorinated organic intermediate characterized by its unique difluoroacetate ester structure. This compound is critical for introducing the difluoromethylenecarboxylate moiety into target molecules, a key step in the synthesis of advanced materials and active pharmaceutical ingredients (APIs). It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those requiring the difluoromethylene group to modulate metabolic stability, lipophilicity, and bioavailability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides where fluorine substitution enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic compounds used in electronic display technologies and organic light-emitting diodes.
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart specific properties such as chemical resistance, thermal stability, or altered surface energy.
• Advanced Organic Synthesis: Employed in cross-coupling reactions, esterifications, and as a reagent for introducing fluorinated synthons in complex molecule construction.
• Chemical Research & Development: A versatile reagent for academic and industrial research exploring new fluorination methodologies and fluorine chemistry.

Basic Information

Item	Detail
Product Name	Ethyl-2,2-Difluoro-2-(4-tert-Butylphenyl)Acetate
CAS No.	1027514-13-1
Molecular Formula	C14H18F2O2
Molecular Weight	256.29 g/mol
Synonyms	Ethyl 4-(tert-butyl)-α,α-difluorobenzeneacetate; 2,2-Difluoro-2-(4-tert-butylphenyl)acetic Acid Ethyl Ester; 4-tert-Butyl-α,α-difluorophenylacetic Acid Ethyl Ester; Ethyl (4-tert-butylphenyl)difluoroacetate; Ethyl 4-(1,1-dimethylethyl)-α,α-difluorobenzeneacetate; DFBEA; Difluoroacetic acid, 2-(4-tert-butylphenyl)-, ethyl ester
EINECS	Contact for details

Quality Control

Every batch of Ethyl-2,2-Difluoro-2-(4-tert-Butylphenyl)Acetate is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes results from HPLC, GC, NMR, and IR spectroscopy. Our quality commitment ensures the material meets the stringent requirements for GMP-grade intermediates and advanced synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (by GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.