Description

1-Bromo-2-(1-Fluoro-Ethyl)-Benzene is a high-purity, halogenated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring both bromine and fluorine substituents on an ethylbenzene core, makes it a versatile precursor for constructing complex molecules. This compound is primarily utilized by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and metabolic diseases.
• Agrochemical Research: Serves as a crucial building block for developing new herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Liquid Crystal & OLED Material Synthesis: Used in the preparation of fluorinated organic semiconductors and liquid crystal compounds for electronic displays.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Fluorine Chemistry Exploration: The (1-fluoro-ethyl) group provides a valuable motif for studying the effects of fluorine introduction on molecular properties like bioavailability and metabolic stability.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for bespoke synthesis projects requiring specific halogenated intermediates.

Basic Information

Product Name	1-Bromo-2-(1-Fluoro-Ethyl)-Benzene
CAS No.	1027513-77-4
Molecular Formula	C8H8BrF
Molecular Weight	203.05 g/mol
Synonyms	1-Bromo-2-(1-fluoroethyl)benzene; 2-Bromo-α-fluoroethylbenzene; (1-Bromo-2-phenylethyl)fluoride; o-Bromo-(1-fluoroethyl)benzene; 1-Fluoro-1-(2-bromophenyl)ethane; 2-(1-Fluoroethyl)bromobenzene; Benzene, 1-bromo-2-(1-fluoroethyl)-
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-(1-Fluoro-Ethyl)-Benzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including GC, HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.