Description

Ethyl 2-(Trifluoromethoxy)Acetate is a specialized fluorinated ester building block of significant interest in advanced organic synthesis. This compound matters for its unique trifluoromethoxy (OCF₃) moiety, which imparts desirable properties like enhanced metabolic stability and lipophilicity to target molecules. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) containing the trifluoromethoxy group, which can improve drug potency and pharmacokinetics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the OCF₃ group enhances biological activity.
• Material Science Research: Serves as a monomer or precursor for developing fluorinated polymers and specialty materials with unique surface properties.
• Organic Synthesis Reagent: Employed in nucleophilic substitution and esterification reactions to introduce the 2-(trifluoromethoxy)acetyl fragment into complex molecular architectures.
• Liquid Crystal & Electronic Chemicals: Potential intermediate in the synthesis of fluorinated components for display technologies and electronic materials.

Basic Information

Product Name	Ethyl 2-(Trifluoromethoxy)Acetate
CAS No.	1027157-11-4
Molecular Formula	C5H7F3O3
Molecular Weight	172.10 g/mol
Synonyms	Ethyl (Trifluoromethoxy)acetate; Acetic acid, 2-(trifluoromethoxy)-, ethyl ester; Ethyl O-(Trifluoromethyl)glycolate; 2-(Trifluoromethoxy)acetic Acid Ethyl Ester; Ethyl α-(Trifluoromethoxy)acetate; OCF3CH2COOEt; TL-1-179
EINECS	Contact for details

Quality Control

Our Ethyl 2-(Trifluoromethoxy)Acetate is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including GC, NMR, and HPLC, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases. Recommended storage temperature is 2-8°C for long-term stability. The container should be kept tightly sealed in a dry environment to minimize moisture uptake and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.360 - 1.380
Density (20°C)	1.25 - 1.35 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.