Description

5-Azaspiro[2.4]heptane-5-carboxylic acid, 1,1-dimethylethyl ester is a high-value, nitrogen-containing spirocyclic building block used in advanced organic synthesis. This compound is critical for medicinal chemistry research, serving as a key intermediate in the development of novel pharmacologically active molecules. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A versatile scaffold for synthesizing potential drug candidates targeting central nervous system (CNS) disorders, metabolic diseases, and other therapeutic areas.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) and improve pharmacokinetic properties.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a component in the linker or warhead design for novel bifunctional degrader molecules.
• Agrochemical Synthesis: An intermediate in the research and development of new active ingredients for crop protection.
• Academic & Contract Research: Employed in universities and CROs for methodological studies in synthetic organic chemistry and the discovery of new chemical entities.
• Custom Synthesis & Scale-Up: A starting material for the contract manufacturing of proprietary compounds under cGMP or non-GMP conditions.

Basic Information

Product Name	5-Azaspiro[2.4]heptane-5-carboxylic acid, 1,1-dimethylethyl ester
CAS No.	1026796-26-8
Molecular Formula	C11H19NO2
Molecular Weight	197.27 g/mol
Synonyms	tert-Butyl 5-azaspiro[2.4]heptane-5-carboxylate; 5-Azaspiro[2.4]heptane-5-carboxylic acid tert-butyl ester; 5-(tert-Butoxycarbonyl)-5-azaspiro[2.4]heptane; 5-Boc-5-azaspiro[2.4]heptane; 5-Azaspiro[2.4]heptane, 5-carboxylic acid, 1,1-dimethylethyl ester; Azaspiroheptane tert-butyl carboxylate; Boc-protected azaspiro[2.4]heptane
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to guarantee identity, purity, and consistency. Certificates of Analysis (COA) detailing specific results for purity, impurities, and other critical parameters are available upon request. We adhere to strict quality management protocols suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.