Description

7-Amino-5-Aza-Spiro[2.4]Heptane-5-Carboxylic Acid tert-Butyl Ester is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic and aza-heterocyclic structure. This compound is critical for medicinal chemistry research and development, serving as a key building block for the synthesis of novel, complex active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract research organizations (CROs) focused on developing new therapeutic agents, particularly in areas requiring sophisticated molecular scaffolds.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of novel drug candidates, especially those targeting the central nervous system (CNS) and other therapeutic areas.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Protease Inhibitor Development: The spirocyclic and aza-amine structure makes it a valuable component for designing potential protease and enzyme inhibitors.
• Fine Chemical Synthesis: Employed in the custom synthesis of complex, high-purity organic molecules for research and pre-clinical development.
• Building Block for Spirocyclic Compounds: Its core structure is leveraged to create diverse libraries of spirocyclic compounds for high-throughput screening.
• Academic & Industrial R&D: Serves as a specialized reagent in academic institutions and industrial R&D departments exploring new chemical entities.

Basic Information

Product Name	7-Amino-5-Aza-Spiro[2.4]Heptane-5-Carboxylic Acid tert-Butyl Ester
CAS No.	1026609-83-5
Molecular Formula	C11H20N2O2
Molecular Weight	212.29 g/mol
Synonyms	tert-Butyl 7-amino-5-azaspiro[2.4]heptane-5-carboxylate; 5-Azaspiro[2.4]heptane-5-carboxylic acid, 7-amino-, 1,1-dimethylethyl ester; 5-tert-Butoxycarbonyl-5-aza-7-aminospiro[2.4]heptane; 7-Amino-5-azaspiro[2.4]heptane-5-carboxylic acid 1,1-dimethylethyl ester; 5-Aza-7-aminospiro[2.4]heptane-5-carboxylic acid tert-butyl ester; Boc-5-aza-7-aminospiro[2.4]heptane; 1026609-83-5
EINECS	Contact for details

Quality Control

Our 7-Amino-5-Aza-Spiro[2.4]Heptane-5-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.