Description

2-Amino-3-Chloromethyl-6-(Trifluoromethyl)Pyridine is a high-value, multi-functional heterocyclic building block characterized by its reactive chloromethyl and amino groups, as well as a stable trifluoromethyl substituent. This compound matters for its critical role in facilitating efficient molecular construction, particularly in the synthesis of complex active pharmaceutical ingredients (APIs) and advanced agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce both amine and halogenated alkyl functionalities into target molecules. Its unique structure offers versatile reactivity for constructing novel compounds with enhanced properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized nitrogen-containing ligands used in homogeneous catalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic materials.
• Custom Synthesis & Contract Manufacturing: A vital building block for custom chemical synthesis services targeting niche and high-value products.
• Bioconjugation & Linker Chemistry: The reactive chloromethyl group allows for attachment to biomolecules or solid supports in probe and linker development.

Basic Information

Product Name	2-Amino-3-Chloromethyl-6-(Trifluoromethyl)Pyridine
CAS No.	1026232-38-1
Molecular Formula	C7H6ClF3N2
Molecular Weight	210.58 g/mol
Synonyms	2-Amino-3-(chloromethyl)-6-(trifluoromethyl)pyridine; 6-(Trifluoromethyl)-3-pyridinemethanamine, 2-amino-3-(chloromethyl)-; 3-(Chloromethyl)-6-(trifluoromethyl)pyridin-2-amine; 2-Amino-3-chloromethyl-6-trifluoromethylpyridine; 2-Pyridinamine, 3-(chloromethyl)-6-(trifluoromethyl)-; (2-Amino-6-trifluoromethyl-pyridin-3-yl)-chloromethane
EINECS	Contact for details

Quality Control

Our 2-Amino-3-Chloromethyl-6-(Trifluoromethyl)Pyridine is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.