Description

2-Amino-6-(Trifluoromethyl)Nicotinonitrile is a high-value, multi-functional heterocyclic building block featuring both amino and nitrile functional groups on a pyridine core. This compound matters for its critical role in facilitating rapid and efficient synthesis of complex molecules, particularly in the development of novel active pharmaceutical ingredients (APIs) and advanced agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate a trifluoromethyl-substituted aminonicotinonitrile scaffold into their target compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors, antiviral agents, and other small molecule therapeutics where the trifluoromethyl group enhances metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the biological activity of the pyridine and trifluoromethyl motifs.
• Material Science Research: Serves as a building block for creating novel organic ligands, metal-organic frameworks (MOFs), and functional polymers with tailored electronic properties.
• Chemical Biology & Probe Development: Employed in the design and synthesis of chemical probes and fluorescent tags for studying biological systems and enzyme activity.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	2-Amino-6-(Trifluoromethyl)Nicotinonitrile
CAS No.	1026039-34-8
Molecular Formula	C7H4F3N3
Molecular Weight	187.12 g/mol
Synonyms	6-(Trifluoromethyl)-2-aminonicotinonitrile; 2-Amino-6-(trifluoromethyl)pyridine-3-carbonitrile; 3-Cyano-6-(trifluoromethyl)pyridin-2-amine; 2-Amino-3-cyano-6-(trifluoromethyl)pyridine; 1026039-34-8; 6-Trifluoromethyl-2-aminonicotinonitrile; 2-Pyridinamine, 3-cyano-6-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 2-Amino-6-(Trifluoromethyl)Nicotinonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed in a dry environment. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.