Description

Lifitegrast is a small-molecule integrin antagonist specifically designed to target inflammation associated with dry eye disease. Its core value proposition lies in its precise mechanism of action, which inhibits T-cell mediated inflammation at the ocular surface. This product is essential for pharmaceutical manufacturers and research institutions developing advanced ophthalmic therapeutics. Lifitegrast CAS NO 1025967-78-5 represents a key active pharmaceutical ingredient for formulations aimed at providing symptomatic relief for chronic ocular conditions.

Application

• Primary Pharmaceutical Ingredient: As the active component in prescription eye drop solutions, such as Xiidra®, for the treatment of dry eye disease.
• Ophthalmic Drug Development: Serves as a critical reference standard and building block in R&D for novel anti-inflammatory ophthalmic drugs.
• Clinical Research Material: Used in preclinical and clinical studies to investigate mechanisms of ocular surface disease and therapeutic efficacy.
• Analytical Standard: Employed as a high-purity standard in HPLC, LC-MS, and other analytical methods for quality control and pharmacokinetic studies.
• Formulation Studies: Utilized in the development of various drug delivery systems, including nanoemulsions or sustained-release formulations for enhanced ocular bioavailability.

Basic Information

Product Name	Lifitegrast
CAS No.	1025967-78-5
Molecular Formula	C₂₉H₂₄ClN₃O₇S₂
Molecular Weight	614.10 g/mol
Synonyms	SAR 1118; (2S)-2-[[(2-Methyl-4-[[(methylsulfonyl)amino]carbonyl]phenyl)amino]carbonyl]-7-(3,5-dimethyl-4-isoxazolyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid; (S)-2-(2-(Benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)acetic acid; Lifitegrastum; Xiidra API; LFA-1 Antagonist SAR1118; UNII-6T3D8B59HQ
EINECS	Contact for details

Quality Control

Our Lifitegrast is manufactured under strict quality management systems, targeting specifications suitable for pharmaceutical development. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We ensure compliance with relevant ICH guidelines and can supply material aligned with GMP standards for advanced clinical trial stages. Certificates of Analysis are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.