Description

n-[4-[(2-Amino-3-Chloropyridin-4-Yl)Oxy]-3-Fluorophenyl]-4-Ethoxy-1-(4-Fluorophenyl)-2-Oxo-1,2-Dihydropyridine-3-Carboxamide is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of next-generation therapeutic agents. This compound matters for its role as a critical building block in the development of targeted kinase inhibitors, offering researchers a reliable and consistent starting material. It is primarily needed by pharmaceutical R&D departments, contract research organizations (CROs), and fine chemical manufacturers engaged in oncology and inflammatory disease drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel kinase inhibitor drug candidates for targeted cancer therapies.
• Biochemical Research: Used in structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Preclinical Development: Serves as a critical material for producing batches of active pharmaceutical ingredients (APIs) for toxicology and early-phase clinical studies.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and scale-up projects.
• Academic Research: Utilized in university and institutional labs for medicinal chemistry and pharmacology research focused on signal transduction pathways.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development and quality control in API manufacturing.

Basic Information

Product Name	n-[4-[(2-Amino-3-Chloropyridin-4-Yl)Oxy]-3-Fluorophenyl]-4-Ethoxy-1-(4-Fluorophenyl)-2-Oxo-1,2-Dihydropyridine-3-Carboxamide
CAS No.	1025720-94-8
Molecular Formula	C25H20ClF2N5O4
Molecular Weight	519.91 g/mol
Synonyms	1025720-94-8; 4-Ethoxy-1-(4-fluorophenyl)-2-oxo-N-[3-fluoro-4-[[2-amino-3-chloro-4-pyridyl]oxy]phenyl]-1,2-dihydropyridine-3-carboxamide; Kinase Inhibitor Intermediate; UNII-9J8K4A8U5C; 9J8K4A8U5C; 1,2-Dihydropyridine-3-carboxamide, 4-ethoxy-1-(4-fluorophenyl)-2-oxo-N-[3-fluoro-4-[[2-amino-3-chloro-4-pyridinyl]oxy]phenyl]-; N-(3-Fluoro-4-((2-amino-3-chloropyridin-4-yl)oxy)phenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
EINECS	Contact for details

Quality Control

Our n-[4-[(2-Amino-3-Chloropyridin-4-Yl)Oxy]-3-Fluorophenyl]-4-Ethoxy-1-(4-Fluorophenyl)-2-Oxo-1,2-Dihydropyridine-3-Carboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing purity, impurities, and other critical parameters are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.