Description

R788 (Fostamatinib Disodium) is a potent and selective spleen tyrosine kinase (SYK) inhibitor, a critical pharmaceutical intermediate and active ingredient. Its primary value lies in its role as the prodrug of the active metabolite R406, enabling targeted therapeutic applications. This compound is essential for pharmaceutical R&D and manufacturing, particularly for organizations developing treatments for immune-mediated conditions such as immune thrombocytopenia (ITP) and autoimmune diseases.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active pharmaceutical ingredient in the development and commercial production of SYK inhibitor therapies.
• Clinical Research Material: Serves as a critical reference standard and bulk material for preclinical studies and clinical trials.
• Oncology & Autoimmune Disease Research: Used in research targeting B-cell lymphomas, rheumatoid arthritis, and other autoimmune disorders where SYK signaling is implicated.
• Prodrug Development Studies: A key compound for studying prodrug metabolism, pharmacokinetics, and targeted drug delivery mechanisms.
• Biochemical Pathway Inhibition: Employed in laboratory settings to specifically inhibit SYK in cellular and molecular biology research.

Basic Information

Product Name	R788 (Fostamatinib Disodium)
CAS No.	1025687-58-4
Molecular Formula	C23H26FN6Na2O9P
Molecular Weight	626.42 g/mol
Synonyms	Fostamatinib Disodium; R788 Disodium; (6-((5-Fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-2,3-dihydrobenzo[b][1,4]dioxine-8-yl)methyl dihydrogen phosphate disodium salt; R 788; R-788; Fostamatinib sodium; Tavalisse (Brand Name); SYK Inhibitor R788
EINECS	Contact for details

Quality Control

Our R788 (Fostamatinib Disodium) is manufactured under strict quality systems to ensure it meets the high-purity standards required for pharmaceutical development. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, with testing performed using validated methods such as HPLC, NMR, and MS. We support compliance with cGMP, ICH Q7 guidelines, and relevant regulatory frameworks for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residual Solvents (GC)	Complies with ICH limits
Heavy Metals	<10 ppm
Single Unknown Impurity	≤0.5%
Total Impurities	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.