Description

(3S)-3-Pyrrolidineacetic Acid, Methyl Ester, Hydrochloride is a high-purity chiral building block and synthetic intermediate of significant importance in modern pharmaceutical research and development. This compound, with the CAS number 1024038-33-2, is valued for its defined stereochemistry and functional group versatility, enabling the construction of complex molecular architectures. It is primarily sought after by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of novel active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and metabolic disorder targets.
• Peptidomimetic Synthesis: Used to introduce constrained proline-like structures into peptide backbones to enhance metabolic stability and biological activity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Agrochemical Research: Potential intermediate in the development of advanced, chiral active ingredients for crop protection.
• Academic & Contract Research: Essential material for universities and CROs (Contract Research Organizations) conducting cutting-edge synthetic chemistry projects.

Basic Information

Product Name	(3S)-3-Pyrrolidineacetic Acid, Methyl Ester, Hydrochloride
CAS No.	1024038-33-2
Molecular Formula	C7H14ClNO2
Molecular Weight	179.65 g/mol
Synonyms	(S)-Methyl 2-(pyrrolidin-3-yl)acetate hydrochloride; Methyl (3S)-3-pyrrolidineacetate hydrochloride; (S)-3-(Methoxycarbonylmethyl)pyrrolidine hydrochloride; (S)-Methyl 3-pyrrolidinylacetate hydrochloride; (3S)-1,2,5,6-Tetrahydropyridine-3-acetic acid methyl ester hydrochloride; (S)-Pyrrolidine-3-acetic acid methyl ester HCl; L-Proline methyl ester derivative hydrochloride
EINECS	Contact for details

Quality Control

Our (3S)-3-Pyrrolidineacetic Acid, Methyl Ester, Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (assay), enantiomeric excess, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.